BUY CHEAP Actos (PIOGLITAZONE)Product info: Diabetes Actos (PIOGLITAZONE) is used with a diet and exercise program and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood). Pioglitazone is in a class of medications called thiazolidinediones. It works by increasing the body's sensitivity to insulin, a natural substance that helps control blood sugar levels. Pioglitazone is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may develop if high blood sugar is not treated).
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• Many payment options: Visa, MasterCard, eCheck, Amex, Wire transfer etc. • Cheapest Website to buy,BEST QUALITY for brand and generic medications! • We are in business for years, so shoping is 100% safe! • Fast & Guaranteed worldwide Delivery! • Free bonus pills for every order! • 30 days money back Guarantee! • 24/7/365 Customer Support! • No prescription required!CLICK HERE TO ENTER, Lowest Prices!******************************************************************Actos Benefits Recent Heart-Attack Patients with DiabetesNovember 26, 2005Actos (pioglitazone) has been shown to reduce the risk of another heart attack among diabetic patients recovering from a heart attack. In a recent study, Actos added to standard therapy for glucose and lipid control proved superior in preventing repeat heart attacks.Analysis of a data subset from 2,445 patients enrolled in the PROspective pioglitAzone Clinical Trial In macroVascular Events (PROACTIVE) trial revealed that taking Actos was associated with a 28% lower risk of recurrent myocardial infarction (MI; P=0.045), according to Erland Erdmann, MD, of the University of KA¶ln in Germany.Actos is in a class of drugs called thiazolidinediones. Thiazolidinediones raise the body's sensitivity to insulin, by binding to and activating a receptor (the peroxisome proliferator-activated receptor-gamma).Subset Analysis is KeyThe subset analysis of data, presented at the American Heart Association (AHA) meeting in Dallas in November, provided a new perspective on Actos's benefits for recent MI patients that had not been evident from the main PROACTIVE study results. In these results, revealed at the European Association for the Study of Diabetes last September, researchers mainly noted that the trial did not meet its primary endpoint.All participants in the subset analysis had had an MI within 6 months before randomization. Participants received treatment according to European Association for the Study of Diabetes guidelines. A total of 55% of participants received statin therapy at baseline and 63% were receiving statins at the study's end, Dr Erdmann said.Actos was associated with a 37% relative decrease in the risk of acute coronary syndrome (P=0.035) and a 19% relative decrease in the composite endpoint of non-fatal MI, coronary revascularization, acute coronary syndrome and death (P=0.034).The primary endpoint in the main PROACTIVE study was a 20% improvement during the time from randomization to the participant's next cardiovascular event (i.e., a composite of all-cause mortality, non-fatal MI, stroke, acute coronary syndrome, coronary revascularization, limb revascularization or amputation above the ankle).In the main PROACTIVE study, Actos was associated with only a 10% improvement , thus missing the primary endpoint. However, these results did confirm that Actos was associated with a 16% reduction in risk of death or recurrent heart attack.PROACTIVE was conducted in 19 European countries and involved 5,238 diabetic participants with prior MI. Participants were randomized either to the highest tolerated dose of Actos (up to 45 mg) or placebo, on top of standard therapy (including insulin, when indicated). Patients were followed for an average of 2.8 years.One problem with the earlier results was the issue of increased congestive heart failure among patients in the Actos arm, according to AHA president Robert H. Eckel, MD, an endocrinologist and professor of medicine at the University of Colorado Health Sciences Center in Denver.Dr Erdmann noted that the subset analysis more clearly elucidates the heart failure question. In total, 63 of the 1,215 patients receiving placebo and 92 of the 1,230 patients receiving Actos were hospitalized for treatment of congestive heart failure.
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