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Order ALDACTONE Generic
« on: September 20, 2009, 05:20:57 pm »
BUY CHEAP ALDACTONEProduct info: Blood Pressure - Aldactone Aldactone: Aldactone is used for treating swelling and fluid retention inpatients with congestive heart failure, cirrhosis, or kidney problems (nephrotic syndrome). It is also used for treatment of high blood pressure. It may also be used to treat or prevent low blood potassium. It may also be used to treat excess secretion of the hormone aldosterone by the adrenal gland. Aldactone is a potassium-sparing diuretic. It works by blocking the hormone aldosterone, causing the kidney to eliminate excess water, save potassium, and lower blood pressure.Fast delivery, No hidden fees, Moneyback guarantee.ORDER IN BULK AND GET THE LOWEST PRICE.* 100% Satisfaction Guarantee* No prescription required!* Customer support available 24/7/365!* Really amazing prices and Free bonuses! Discount system!* Fast worldwide shipping! 30 days money back guarantee! Free AirMail & Courier shipping for large orders.* Many payment options: Visa, Amex, MasterCard, Diners Club, JCB, eCheck, Wire transfer etc.CLICK HERE TO ENTER, Lowest Prices!******************************************************************AldactoneGeneric Name: spironolactoneDosage Form: Tablets, USPWarningSpironolactone has been shown to be a tumorigen in chronic toxicity studies in rats (see Precautions). Aldactone should be used only in those conditions described under Indications and Usage. Unnecessary use of this drug should be avoided.Aldactone DescriptionAldactone oral tablets contain 25 mg, 50 mg, or 100 mg of the aldosterone antagonist spironolactone, 17-hydroxy-7?-mercapto-3-oxo-17?-pregn-4-ene-21-carboxylic acid ?-lactone acetate, which has the following structural formula:Spironolactone is practically insoluble in water, soluble in alcohol, and freely soluble in benzene and in chloroform.Inactive ingredients include calcium sulfate, corn starch, flavor, hypromellose, iron oxide, magnesium stearate, polyethylene glycol, povidone, and titanium dioxide.ACTIONS / CLINICAL PHARMACOLOGYMechanism of actionAldactone (spironolactone) is a specific pharmacologic antagonist of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule. Aldactone causes increased amounts of sodium and water to be excreted, while potassium is retained. Aldactone acts both as a diuretic and as an antihypertensive drug by this mechanism. It may be given alone or with other diuretic agents which act more proximally in the renal tubule.Aldosterone antagonist activityIncreased levels of the mineralocorticoid, aldosterone, are present in primary and secondary hyperaldosteronism. Edematous states in which secondary aldosteronism is usually involved include congestive heart failure, hepatic cirrhosis, and the nephrotic syndrome. By competing with aldosterone for receptor sites, Aldactone provides effective therapy for the edema and ascites in those conditions. Aldactone counteracts secondary aldosteronism induced by the volume depletion and associated sodium loss caused by active diuretic therapy.Aldactone is effective in lowering the systolic and diastolic blood pressure in patients with primary hyperaldosteronism. It is also effective in most cases of essential hypertension, despite the fact that aldosterone secretion may be within normal limits in benign essential hypertension.Through its action in antagonizing the effect of aldosterone, Aldactone inhibits the exchange of sodium for potassium in the distal renal tubule and helps to prevent potassium loss.Aldactone has not been demonstrated to elevate serum uric acid, to precipitate gout, or to alter carbohydrate metabolism.PharmacokineticsSpironolactone is rapidly and extensively metabolized. Sulfur-containing products are the predominant metabolites and are thought to be primarily responsible, together with spironolactone, for the therapeutic effects of the drug. The following pharmacokinetic data were obtained from 12 healthy volunteers following the administration of 100 mg of spironolactone (Aldactone film-coated tablets) daily for 15 days. 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