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Unnecessary use of this drug should be avoided.Aldactone DescriptionAldactone oral tablets contain 25 mg, 50 mg, or 100 mg of the aldosterone antagonist spironolactone, 17-hydroxy-7?-mercapto-3-oxo-17?-pregn-4-ene-21-carboxylic acid ?-lactone acetate, which has the following structural formula:Spironolactone is practically insoluble in water, soluble in alcohol, and freely soluble in benzene and in chloroform.Inactive ingredients include calcium sulfate, corn starch, flavor, hypromellose, iron oxide, magnesium stearate, polyethylene glycol, povidone, and titanium dioxide.ACTIONS / CLINICAL PHARMACOLOGYMechanism of actionAldactone (spironolactone) is a specific pharmacologic antagonist of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule. Aldactone causes increased amounts of sodium and water to be excreted, while potassium is retained. Aldactone acts both as a diuretic and as an antihypertensive drug by this mechanism. It may be given alone or with other diuretic agents which act more proximally in the renal tubule.Aldosterone antagonist activityIncreased levels of the mineralocorticoid, aldosterone, are present in primary and secondary hyperaldosteronism. Edematous states in which secondary aldosteronism is usually involved include congestive heart failure, hepatic cirrhosis, and the nephrotic syndrome. By competing with aldosterone for receptor sites, Aldactone provides effective therapy for the edema and ascites in those conditions. Aldactone counteracts secondary aldosteronism induced by the volume depletion and associated sodium loss caused by active diuretic therapy.Aldactone is effective in lowering the systolic and diastolic blood pressure in patients with primary hyperaldosteronism. It is also effective in most cases of essential hypertension, despite the fact that aldosterone secretion may be within normal limits in benign essential hypertension.Through its action in antagonizing the effect of aldosterone, Aldactone inhibits the exchange of sodium for potassium in the distal renal tubule and helps to prevent potassium loss.Aldactone has not been demonstrated to elevate serum uric acid, to precipitate gout, or to alter carbohydrate metabolism.PharmacokineticsSpironolactone is rapidly and extensively metabolized. Sulfur-containing products are the predominant metabolites and are thought to be primarily responsible, together with spironolactone, for the therapeutic effects of the drug. The following pharmacokinetic data were obtained from 12 healthy volunteers following the administration of 100 mg of spironolactone (Aldactone film-coated tablets) daily for 15 days. 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« on: September 20, 2009, 12:04:48 pm »

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Pioglitazone is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may develop if high blood sugar is not treated).Fast delivery, No hidden fees, Moneyback guarantee.ORDER IN BULK AND GET THE LOWEST PRICE.• Many payment options: Visa, MasterCard, eCheck, Amex, Wire transfer etc. • Cheapest Website to buy,BEST QUALITY for brand and generic medications! • We are in business for years, so shoping is 100% safe! • Fast & Guaranteed worldwide Delivery! • Free bonus pills for every order! • 30 days money back Guarantee! • 24/7/365 Customer Support! • No prescription required!CLICK HERE TO ENTER, Lowest Prices!******************************************************************Actos Benefits Recent Heart-Attack Patients with DiabetesNovember 26, 2005Actos (pioglitazone) has been shown to reduce the risk of another heart attack among diabetic patients recovering from a heart attack. In a recent study, Actos added to standard therapy for glucose and lipid control proved superior in preventing repeat heart attacks.Analysis of a data subset from 2,445 patients enrolled in the PROspective pioglitAzone Clinical Trial In macroVascular Events (PROACTIVE) trial revealed that taking Actos was associated with a 28% lower risk of recurrent myocardial infarction (MI; P=0.045), according to Erland Erdmann, MD, of the University of KA¶ln in Germany.Actos is in a class of drugs called thiazolidinediones. Thiazolidinediones raise the body's sensitivity to insulin, by binding to and activating a receptor (the peroxisome proliferator-activated receptor-gamma).Subset Analysis is KeyThe subset analysis of data, presented at the American Heart Association (AHA) meeting in Dallas in November, provided a new perspective on Actos's benefits for recent MI patients that had not been evident from the main PROACTIVE study results. In these results, revealed at the European Association for the Study of Diabetes last September, researchers mainly noted that the trial did not meet its primary endpoint.All participants in the subset analysis had had an MI within 6 months before randomization. Participants received treatment according to European Association for the Study of Diabetes guidelines. A total of 55% of participants received statin therapy at baseline and 63% were receiving statins at the study's end, Dr Erdmann said.Actos was associated with a 37% relative decrease in the risk of acute coronary syndrome (P=0.035) and a 19% relative decrease in the composite endpoint of non-fatal MI, coronary revascularization, acute coronary syndrome and death (P=0.034).The primary endpoint in the main PROACTIVE study was a 20% improvement during the time from randomization to the participant's next cardiovascular event (i.e., a composite of all-cause mortality, non-fatal MI, stroke, acute coronary syndrome, coronary revascularization, limb revascularization or amputation above the ankle).In the main PROACTIVE study, Actos was associated with only a 10% improvement , thus missing the primary endpoint. 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« on: September 17, 2009, 07:43:04 am »

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